(2005) SeqDoC: rapid SNP and mutation detection by direct comparison of DNA sequence chromatograms, BMC Bioinformatics 6, 133.Įwing, B., Green, P. (2005) InSNP: a tool for automated detection and visualization of SNPs and InDels, Hum Mutat 26, 11–19.Ĭrowe, M. Manaster, C., Zheng, W., Teuber, M., Wachter, S., Doring, F., Schreiber, S., Hampe, J. (2005) novoSNP, a novel computational tool for sequence variation discovery, Genome Res 15, 436–442. Weckx, S., Del-Favero, J., Rademakers, R., Claes, L., Cruts, M., De Jonghe, P., Van Broeckhoven, C., De Rijk, P.
#4PEAKS ALIGN SEQUENCE SOFTWARE#
(2005) SNPdetector: a software tool for sensitive and accurate SNP detection, PLoS Comput Biol 1, e53. A., Yakub, I., Wei, S., Sood, R., Rowe, W., Liu, P. (2003) Automated identification of single nucleotide polymorphisms from sequencing data, J Bioinform Comput Biol 1, 253–265. Takahashi, M., Matsuda, F., Margetic, N., Lathrop, M. (1999) A general approach to single-nucleotide polymorphism discovery, Nat Genet 23, 452–456. (2001) Automated fluorescent DNA sequencing on the ABI PRISM 377, Methods Mol Biol 167, 119–152. (1992) DNA sequencing with chain-terminating inhibitors. The 4Peaks app provides support for most popular sequence file formats, allows you to effortlessly edit the sequence and compare the results with other databases, comes with basic but efficient searching capabilities, and a lot more.Sanger, F., Nicklen, S., Coulson, A.
#4PEAKS ALIGN SEQUENCE MAC#
Robust sequence trace analysis and editing Mac app designed to help you observe DNA mutations with easeĤPeaks is one of the best tools available on the Mac platform for people who work with DNA sequence trace files on a daily basis. In addition, you can use the BLAST (Basic Local Alignment Search Tool) algorithm to compare your DNA sequences with other nucleotide samples hosted on the NCBI (National Center for Biotechnology Information) website. Since the app includes translation functions, you will be able to visualize the effect of a certain mutation with minimal effort. Uncomplicated DNA analysis tool with a user friendly design and amino-acid translation capabilitiesĤPeaks comes with a basic search tool which you can employ to quickly highlight a specific motif: you can use the predefined ones, or effortlessly make your own. At the same time, 4Peaks offers support for integrating user developed plug-ins that deal with specific tasks. The next step is to open the DNA sequence file you want to analyze: 4Peaks will generate a visual representation that can be easily edited by double clicking on the call you want to change.įor your convenience, 4Peaks comes with multiple translation dictionaries and BLAST algorithms: simply choose the ones you want to employ via the appropriate menus. Like with many other OS X software solutions, the 4Peaks installation process is reduced to dragging and dropping the app to your disk. Straightforward DNA sequence trace editor and viewer, with support for protein and DNA analysis plug-ins Moreover, although quite minimalist looking, the 4Peaks utility is able to handle most sequence trace file formats, such as SCF, ZTR, EXP, PLN, BIO, ALF, CTF, and a lot more. 4Peaks is a comprehensive Mac app designed to provide uncomplicated yet highly efficient tools for viewing and analyzing information extracted while sequencing DNA samples.